Maternal Lipid Metabolism Directs Fetal Liver Programming following Nutrient Stress

Maternal Lipid Metabolism and Its Implications for Fetal Growth

During gestation, the mother has to adapt her own metabolism to support a continuous extraction of nutrients through the placenta to sustain fetal development. Quantitatively, glucose and amino acids are the most abundant of these nutrients crossing the placenta (1,2), and the continuous dependence of the fetus on these compounds is well-known. However, the placenta is practically impermeable t...

Fetal programming by maternal stress: Insights from a conflict perspective

Protein restriction during pregnancy affects maternal liver lipid metabolism and fetal brain lipid composition in the rat.

Suboptimal developmental environments program offspring to lifelong metabolic problems. The aim of this study was to determine the impact of protein restriction in pregnancy on maternal liver lipid metabolism at 19 days of gestation (dG) and its effect on fetal brain development. Control (C) and restricted (R) mothers were fed with isocaloric diets containing 20 and 10% of casein. At 19 dG, mat...

Fetal programming by maternal stress: Insights from a conflict perspective.

Maternal stress during pregnancy has pervasive effects on the offspring's physiology and behavior, including the development of anxious, reactive temperament and increased stress responsivity. These outcomes can be seen as the result of adaptive developmental plasticity: maternal stress hormones carry useful information about the state of the external world, which can be used by the developing ...

Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity

Changes in the maternal nutritional environment during fetal development can influence offspring's metabolic risk in later life. Animal models have demonstrated that offspring of diet-induced obese dams develop metabolic complications, including nonalcoholic fatty liver disease. In this study we investigated the mechanisms in young offspring that lead to the development of nonalcoholic fatty li...